Nonallelic behavior of rabbit variable-region allotypes.

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Nonallelic behavior of rabbit variable-region allotypes

Group a allotypes not detected by qualitative typing or anticipated from breeding data (latent allotypes) were detected at low levels in 50% of normal rabbit sera tested. The latent allotypes, which were serologically identical to allotypes of pooled IgG, were detected in sera from rabbits with all possible combinations of group a allotypes and their occurrence in individual rabbits was transit...

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Genetic studies have indicated that immunoglobulin allotypes are inherited as codominant Mendelian alleles and that their synthesis is controlled by genes at three unlinked loci (1). However, recent evidence has challenged the notion that immunoglobulin allotypes are encoded by allelic structural genes, and has led to the suggestion that individuals may possess complex groups of structural gene...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1975

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.141.6.1448